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pentobarbital will lessen the extent or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or influence of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with solid CYP3A4 inducers lessens plasma c